Home > News > Content
Protective Effect Of Fish Oil On Lipopolysaccharide-stimulated Intestinal Injury In Piglets
Aug 06, 2017

                The purpose of this study was to investigate the protective effect of fish oil on lipopolysaccharide (LPS) stimulation of intestinal injury in piglets. The 32-head (28±3)-day Age and weight (8.91±0. $number) kg were randomly divided into 4 groups, 4 repetitions per group, 2 pigs for each (column) and 1 heads of male and female. The 2x2 factor design was used to test the main factors including: 1 feed treatment (5% oil or 5% corn), 2 immune stress (LPS or saline injections), and D in the trial period.Fish Oil

                On the 19th day of the trial, 1/2 of the pigs in each diet group were injected with 150μg/kg bw LPs and 1/2 injections of sterile saline as control. The piglets were slaughtered after injecting LPs 4 H and the small intestine samples were taken for testing. The results showed that: 1 LPs stimulation resulted in a significant decrease of villi height and crypt depth in Jejunum and Ileum (P-05), and fish oil significantly increased the height of villi, crypt depth and villus height/crypt Depth (P-05). 2 LPs stimulation resulted in a significant decrease in the activity of maltose enzymes, lactase and sucrose enzymes in jejunum mucosa p. 05; fish oil significantly increased the activity of the Jejunum sucrose enzyme (P-05), and the effect of fish oil on the activity of Ileal lactase was significantly related to LPs stimulation (P-05), which was significantly increased the activity of ileal lactase in the Saline group (p.). 3 LPs stimulation significantly increased the levels of tumor necrosis factor alpha (tnf-α) and prostaglandin E2 (PGE2) in Jejunum and Ileum (p. 05), and fish oil significantly reduced the content of Tnf-α in Jejunum (P-05) and inhibited the inhibition of PGE2 in Jejunum (p. 10). 4 LPs stimulation resulted in a significant increase in the expression of kappab (nf-κb) protein in the mucosa of Jejunum and Ileum (p. 05), while fish oil effectively reduced the expression of nf-κb protein in the ileum (P-05).Fish Oil

              The results suggest that: fish oil alleviates the intestinal damage caused by LPs, and fish oil may inhibit the secretion of inflammatory mediators by affecting the expression of nf-κb protein in the gut to play a protective role.Fish Oil



Subscribe to our email list
Sign up with your name and email to get the latest proway updates, exclusive access to promotions, sales events, pre-order sales & more!
Connect with Baihe
Become our fan, follow us & subscribe for the latest updates and deals
QR Code
  • About Us
  • Products
  • News
  • Industry knowledge
  • Quality Control
  • Contact Us
  • Feedback
  • Copyright © Weihai Baihe Biology Technological Co.,Ltd. All rights reserved.